Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation.

@article{Morin2007FunctionalEO,
  title={Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation.},
  author={Caroline Morin and Marco Sirois and Vincent Echav{\'e} and M{\'a}rcio Miguel Gomes and Elisabeth Rousseau},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 4},
  pages={
          L1037-44
        }
}
Airway smooth muscle (ASM) metabolizes arachidonic acid (AA) through various enzymatic pathways, including cytochrome P-450 (CYP-450) omega-hydroxylase, which leads to the production of 20-hydroxyeicosatetraenoic acid (20-HETE). The goal of this study was to delineate the mode of action of 20-HETE in human ASM cells. Isometric tension measurements demonstrated that 20-HETE induced a concentration-dependent relaxant effect in ASM on bronchi precontracted with either methacholine or AA. Relaxing… CONTINUE READING
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Arachidonic acid and ion channels: an update.

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