Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis.

  title={Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis.},
  author={Alex Fornito and Ben J. Harrison and Emmeline Goodby and Anna S Dean and Cinly Ooi and Pradeep J. Nathan and Belinda R Lennox and Peter B. Jones and John Suckling and Edward T. Bullmore},
  journal={JAMA psychiatry},
  volume={70 11},
IMPORTANCE Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders, although the differential roles played by dorsal and ventral systems in mediating risk for psychosis have been contentious. OBJECTIVE To use resting-state functional magnetic resonance imaging to characterize disease-related, risk-related, and symptom-related changes of corticostriatal functional circuitry in patients with first-episode psychosis and their… CONTINUE READING
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