Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks

@inproceedings{Hu2015FunctionalDA,
  title={Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks},
  author={Ting Hu and Angeline S. Andrew and Margaret R. Karagas and Jason H. Moore},
  booktitle={BioData Mining},
  year={2015}
}
The interaction effect among multiple genetic factors, i.e. epistasis, plays an important role in explaining susceptibility on common human diseases and phenotypic traits. The uncertainty over the number of genetic attributes involved in interactions poses great challenges in genetic association studies and calls for advanced bioinformatics methodologies. Network science has gained popularity in modeling genetic interactions thanks to its structural characterization of large numbers of entities… CONTINUE READING