Functional downregulation of the E-cadherin/catenin complex leads to loss of contact inhibition of motility and of mitochondrial activity, but not of growth in confluent epithelial cell cultures.

@article{Bracke1997FunctionalDO,
  title={Functional downregulation of the E-cadherin/catenin complex leads to loss of contact inhibition of motility and of mitochondrial activity, but not of growth in confluent epithelial cell cultures.},
  author={Marc E. Bracke and Herman T Depypere and Caroline Labit and Veerle Van Marck and Krist'l M Vennekens and Stefan J T Vermeulen and I Maelfait and Jan Philipp{\'e} and Rudolphe F Serreyn and Marc M. K. Mareel},
  journal={European journal of cell biology},
  year={1997},
  volume={74 4},
  pages={342-9}
}
When epithelial cells reach confluency in vitro, a number of energy-requiring activities such as growth and motility are contact-inhibited. We investigated the possible role of the E-cadherin/catenin complex, which acts as an invasion suppressor, in contact inhibition. Three strategies for modulation of the complex were used. Firstly, the cell-cell adhesion and signal transduction functions of E-cadherin were neutralized immunologically in human MCF-7/6 mammary carcinoma cells possessing a… CONTINUE READING

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