Functional domains of the Rsp5 ubiquitin-protein ligase.

@article{Wang1999FunctionalDO,
  title={Functional domains of the Rsp5 ubiquitin-protein ligase.},
  author={Gang Wang and Joy C. Yang and Jon M Huibregtse},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 1},
  pages={
          342-52
        }
}
RSP5, an essential gene of Saccharomyces cerevisiae, encodes a hect domain E3 ubiquitin-protein ligase. Hect E3 proteins have been proposed to consist of two broad functional domains: a conserved catalytic carboxyl-terminal domain of approximately 350 amino acids (the hect domain) and a large, nonconserved amino-terminal domain containing determinants of substrate specificity. We report here the mapping of the minimal region of Rsp5 necessary for its essential in vivo function, the minimal… CONTINUE READING
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Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis.

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