Functional domains and phosphorylation of the orphan receptor Nur77.

  title={Functional domains and phosphorylation of the orphan receptor Nur77.},
  author={Ian Davis and Thomas G. Hazel and R H Chen and John Blenis and Lester F. Lau},
  journal={Molecular endocrinology},
  volume={7 8},
Nur77 represents a unique class within the steroid receptor superfamily since its synthesis is tightly regulated by extracellular signals and it is capable of potent transactivation activity in the absence of an exogenously added ligand. In this study, we sought to dissect the functional domains regulating the activities of Nur77 by deletion mapping. We demonstrate that whereas the transactivation activity of Nur77 resides in the amino-terminal domain, the carboxy-terminal domain regulates this… CONTINUE READING


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