Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.

@article{ONeill1995FunctionalDA,
  title={Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.},
  author={Elizabeth M. O'Neill and Michael C. Ellis and Gerald M. Rubin and Robert Tjian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 14},
  pages={6557-61}
}
The glass gene is required for proper photo-receptor differentiation during development of the Drosophila eye glass codes for a DNA-binding protein containing five zinc fingers that we show is a transcriptional activator. A comparison of the sequences of the glass genes from two species of Drosophila and a detailed functional domain analysis of the Drosophila melanogaster glass gene reveal that both the DNA-binding domain and the transcriptional-activation domain are highly conserved between… CONTINUE READING