Functional diversity of helper T lymphocytes

@article{Abbas1996FunctionalDO,
  title={Functional diversity of helper T lymphocytes},
  author={A. Abbas and K. Murphy and A. Sher},
  journal={Nature},
  year={1996},
  volume={383},
  pages={787-793}
}
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy. 
View on Nature
ncbi.nlm.nih.gov
4,655 Citations
Highly Influential Citations
184
Background Citations
1,523
Methods Citations
38
Results Citations
34

4,655 Citations

Citation Type

Citation Type

T-cell subsets: Recruiting the right kind of help
The qualitative features of immune responses are influenced by the polarization of helper T cells towards two distinct phenotypes, Th1 and Th2. Recent evidence suggests that these helper cell subsets… Expand
Development of CD4+ effector T cells and susceptibility to infectious diseases.
The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using… Expand
Helper T cell diversity and plasticity.
TLDR
This review highlights recent advances that pertain to this topic and the mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity and highlights the importance of recognition of new subsets. Expand
Helper T cell differentiation: a role for SAP?
TLDR
Evidence is emerging that a signaling pathway involving the SAP molecule may play an important role in this differentiation process of periperal T cells into TH1 and TH2 subsets. Expand
Helper T cell subsets: heterogeneity, functions and development.
TLDR
Elucidating the cellular and molecular pathways responsible for helper T cell differentiation will ultimately permit the manipulation of immune responses to pathogens, as well as the development of novel vaccine strategies. Expand
Heterogeneity of CD4(+) and CD8(+) T cells.
TLDR
This work has shown that T-cell populations display additional diversity in terms of phenotype, anatomical distribution and effector function in relation to antigen. Expand
T-cell differentiation: Commitment factors for T helper cells
Abstract Cytokines are dominant factors in driving the development of T helper cell subsets via specific signaling pathways. Transcription factors specific to the T helper cell lineages have also… Expand
T lymphocyte differentiation in the periphery.
  • K. Murphy
  • Biology, Medicine
  • Current opinion in immunology
  • 1998
TLDR
Advances in Th1 development have included greater understanding of IL-12 receptors in Th2 development, data regarding IFN-gamma gene expression and clarification of the action of the new cytokine IL-18. Expand
How the MHC selects Th1/Th2 immunity.
  • J. Murray
  • Biology, Medicine
  • Immunology today
  • 1998
TLDR
How TCR affinity and ligand density might interface with innate forces in the selection of CD4+ T-cell functions is discussed. Expand
Barrier immunity and IL-17.
TLDR
The development and function of T(H)17 cells, and their relationship with T(R) cells are discussed, which also have a critical function in barrier protection and immune regulation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 91 REFERENCES
A functional dichotomy in CD4+ T lymphocytes.
TLDR
Recent evidence from studies of cloned T-cell lines and normal T- cell populations suggests that two major functional phenotypes exist, each having a distinct role to play in protective immunity. Expand
Mechanisms underlying T-cell tolerance.
TLDR
Model systems in which transgenic expression of TCRs, foreign antigens, or both allows visualization of otherwise undetectable mechanisms can provide a strikingly powerful supplement to the primary mechanism of tolerance, thymic clonal deletion. Expand
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
TLDR
Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed. Expand
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.
TLDR
The thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them is explored. Expand
Th1 and Th2 subsets: paradigms lost?
  • A. Kelso
  • Biology, Medicine
  • Immunology today
  • 1995
TLDR
It is argued that cytokine-producing T cells cannot be classified into discrete subsets, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of the possible extreme phenotypes. Expand
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
TLDR
Results show that stimulation in the presence of polarizing stimuli results in cells producing either IFN-gamma or IL-4, but that coproduction can occur in rare cells under defined conditions. Expand
IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.
TLDR
The experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype. Expand
T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance.
TLDR
The value of the transgenic approach is that it can overcome the low frequency of peptide-specific T cells occurring in normal animals, and also provide a tissue-specific, cognate antigen that is absent in controls. Expand
Stability of Th1 and Th2 populations.
TLDR
It is shown that IL-12 and IL-4 are the most potent stimuli for the differentiation of naive T cells to effector populations and the stability of Th2 populations may limit the ability to regulate Th2-dominant responses in pathologic situations. Expand
Differential regulation of murine T lymphocyte subsets.
TLDR
Understanding the mechanisms that differentially regulate the various kinds of T cells, in addition to providing insights into the molecular events associated with activation of those subsets, should facilitate modulation of their activities in vivo, making it possible to influence favorably the outcome of disease processes. Expand
...
1
2
3
4
5
...