Functional diversity of helper T lymphocytes

@article{Abbas1996FunctionalDO,
  title={Functional diversity of helper T lymphocytes},
  author={A. Abbas and K. Murphy and A. Sher},
  journal={Nature},
  year={1996},
  volume={383},
  pages={787-793}
}
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy. 
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