Functional diversity of helper T lymphocytes

  title={Functional diversity of helper T lymphocytes},
  author={Abul K. Abbas and Kenneth M. Murphy and Alan Sher},
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy. 
T-cell subsets: Recruiting the right kind of help
Development of CD4+ effector T cells and susceptibility to infectious diseases.
The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using
Helper T cell diversity and plasticity.
Helper T cell differentiation: a role for SAP?
Evidence is emerging that a signaling pathway involving the SAP molecule may play an important role in this differentiation process of periperal T cells into TH1 and TH2 subsets.
Helper T cell subsets: heterogeneity, functions and development.
T-cell differentiation: Commitment factors for T helper cells
T lymphocyte differentiation in the periphery.
  • K. Murphy
  • Biology, Medicine
    Current opinion in immunology
  • 1998
Barrier immunity and IL-17.
How the MHC selects Th1/Th2 immunity.
Dendritic Cells and Tolerance
Dendritic cells as potent antigen presenting cells play a pivotal role in the induction and elicitation of allergie immune responses and allow distinct manipulations of their function.


TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
Th1 and Th2 subsets: paradigms lost?
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
Results show that stimulation in the presence of polarizing stimuli results in cells producing either IFN-gamma or IL-4, but that coproduction can occur in rare cells under defined conditions.
Differential regulation of murine T lymphocyte subsets.
Understanding the mechanisms that differentially regulate the various kinds of T cells, in addition to providing insights into the molecular events associated with activation of those subsets, should facilitate modulation of their activities in vivo, making it possible to influence favorably the outcome of disease processes.
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
The results show that both types of TH cells induce the secretion of IgM and IgG3, whereas clones of TH1 and TH2 cells specifically induce antigen-specific B cells to secrete IgG2a and Igg1, respectively.
CD30 and type 2 T helper (Th2) responses
CD30 is one of the members of the tumor necrosis factor receptor superfamily, originally described as a marker of Reed‐Sternberg and Hodgkin's cells in Hodgkin's lymphoma. CD30 appears to be
Regulation of immunity to parasites by T cells and T cell-derived cytokines.
Research on T lymphocyte-parasite interactions is crucial for the design of effective vaccines and immunotherapies and thus has broad practical as well as theoretical ramifications.