Functional diversity of helper T lymphocytes
@article{Abbas1996FunctionalDO, title={Functional diversity of helper T lymphocytes}, author={Abul K. Abbas and Kenneth M. Murphy and Alan Sher}, journal={Nature}, year={1996}, volume={383}, pages={787-793} }
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.
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