Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons.

@article{Tottene1996FunctionalDO,
  title={Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons.},
  author={Angelita Tottene and Alessandra Moretti and Daniela Pietrobon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 20},
  pages={6353-63}
}
By combining single-channel and whole-cell patch-clamp recordings, we have established the sensitivity to omega-agatoxin IVA and omega-conotoxin MVIIC (SNX-230) of G1, G2, and G3, the three novel non-L-, non-N-type Ca2+ channels characterized previously in rat cerebellar granule cells. G1 channels were blocked irreversibly by both omega-conotoxin MVIIC and low doses of omega-agatoxin IVA (saturation at 50 nM). Thus, according to pharmacological criteria, G1 channels must be classified as P-type… CONTINUE READING

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