Functional diversification of centrins and cell morphological complexity.

@article{Gogendeau2008FunctionalDO,
  title={Functional diversification of centrins and cell morphological complexity.},
  author={Delphine Gogendeau and Catherine Klotz and Olivier Arnaiz and Agata Malinowska and Michał Dadlez and Nicole Garreau de Loubresse and Françoise Ruiz and France Koll and Janine Beisson},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 1},
  pages={
          65-74
        }
}
In addition to their key role in the duplication of microtubule organising centres (MTOCs), centrins are major constituents of diverse MTOC-associated contractile arrays. A centrin partner, Sfi1p, has been characterised in yeast as a large protein carrying multiple centrin-binding sites, suggesting a model for centrin-mediated Ca2+-induced contractility and for the duplication of MTOCs. In vivo validation of this model has been obtained in Paramecium, which possesses an extended contractile… CONTINUE READING

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