Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

@inproceedings{Shi2013FunctionalDO,
  title={Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans},
  author={Lei Shi and Ming Li and Qiang Lin and Xue-bin Qi and Bing Su},
  booktitle={BMC Biology},
  year={2013}
}
One of the key genes that regulate human brain size, MCPH1 has evolved under strong Darwinian positive selection during the evolution of primates. During this evolution, the divergence of MCPH1 protein sequences among primates may have caused functional changes that contribute to brain enlargement. To test this hypothesis, we used co-immunoprecipitation and reporter gene assays to examine the activating and repressing effects of MCPH1 on a set of its down-stream genes and then compared the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 53 references

Molecular evolution of microcephalin, a gene determining human brain size.

Human molecular genetics • 2004
View 5 Excerpts
Highly Influenced

doi:10.1186/1741-7007-11-62 Cite this article as: Shi et al.: Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

BMC Biology • 2013
View 1 Excerpt

MCPH 1 / BRIT 1 represses transcription of the human telomerase reverse transcriptase

A Blais, D Monte, F Pouliot, C Labrie
gene • 2012