Functional dissociation of CD8 alpha's Ig homologue and connecting peptide domains.

@article{Meyerson1996FunctionalDO,
  title={Functional dissociation of CD8 alpha's Ig homologue and connecting peptide domains.},
  author={Howard J. Meyerson and Julia He Huang and John D. Fayen and H M Tsao and Robert R Getty and Neil S. Greenspan and Mark L. Tykocinski},
  journal={Journal of immunology},
  year={1996},
  volume={156 2},
  pages={574-84}
}
The contribution of the CD8 alpha.IgV homologue domain to class I MHC binding was evaluated using a series of chimeric human CD8 alpha:Fc polypeptides incorporating alternative CD8 alpha extracellular domain components. Using a nonisotopic cellfree physical binding assay, those Fc chimeras encompassing the CD8 alpha.IgV homologue domain only (dissociated from the 48-amino acid CD8 alpha connecting peptide) were shown to retain the capacity of the complete CD8 alpha extracellular domain to bind… CONTINUE READING