Functional dissection of the mouse Hox‐a5 gene.

@article{Zhao1996FunctionalDO,
  title={Functional dissection of the mouse Hox‐a5 gene.},
  author={J. J. Zhao and R. Lazzarini and L. Pick},
  journal={The EMBO Journal},
  year={1996},
  volume={15}
}
The Hox genes are clustered in evolutionarily conserved complexes and encode DNA binding proteins that determine positional identity. Ubiquitous expression of fly or mammalian Hox proteins in Drosophila embryos provides an assay for gene function, since different Hox genes induce characteristic homeotic transformations. Drosophila Sex combs reduced (Scr) and its murine cognate Hox‐a5 produce identical transformations in transgenic flies. To study the contributions of domains conserved between… Expand
Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context
Hox specificity unique roles for cofactors and collaborators.
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