Functional dissection of the granzyme family: cell death and inflammation.

  title={Functional dissection of the granzyme family: cell death and inflammation.},
  author={Desiree A. Anthony and Daniel Andrews and Sally V. Watt and Joseph A. Trapani and Mark J Smyth},
  journal={Immunological reviews},
  volume={235 1},
Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected with intracellular pathogens. One mechanism, known as granule exocytosis, employs the secretory granules of these lymphocytes. These include the pore-forming protein perforin (pfp) and a family of serine proteases known as granzymes that cleave and activate effector molecules within the target cell. Over the past two decades, the study of granzymes has largely focused on the ability of these serine… CONTINUE READING


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