Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani.

@article{Sengupta2003FunctionalDO,
  title={Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani.},
  author={T. Sengupta and Mandira Mukherjee and C. Mandal and A. Das and H. Majumder},
  journal={Nucleic acids research},
  year={2003},
  volume={31 18},
  pages={
          5305-16
        }
}
The amino acid sequences of the C-terminal domain (CTD) of the type II DNA topoisomerases are divergent and species specific as compared with the highly conserved N-terminal and central domains. A set of C-terminal deletion mutants of Leishmania donovani topoisomerase II was constructed. Removal of more than 178 amino acids out of 1236 amino acid residues from the C-terminus inactivates the enzyme, whereas removal of 118 amino acids or less has no apparent effect on the ability of the parasite… Expand
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