Functional dissection of signal and noise in MT and LIP during decision-making

@article{Yates2017FunctionalDO,
  title={Functional dissection of signal and noise in MT and LIP during decision-making},
  author={Jacob L. Yates and Il Memming Park and Leor N. Katz and Jonathan W. Pillow and Alexander C. Huk},
  journal={Nature neuroscience},
  year={2017},
  volume={20},
  pages={1285 - 1292}
}
During perceptual decision-making, responses in the middle temporal (MT) and lateral intraparietal (LIP) areas appear to map onto theoretically defined quantities, with MT representing instantaneous motion evidence and LIP reflecting the accumulated evidence. However, several aspects of the transformation between the two areas have not been empirically tested. We therefore performed multistage systems identification analyses of the simultaneous activity of MT and LIP during individual decisions… 
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TLDR
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TLDR
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Stimulus-choice (mis)alignment in primate area MT
TLDR
Using a statistical nonlinear dimensionality reduction technique on single-trial ensemble recordings from the middle temporal area during perceptual-decision-making, low-dimensional latent factors are extracted that captured the population-wide fluctuations and found that a large component of the choice information resides in the subspace orthogonal to the stimulus representation inconsistent with the optimal readout view.
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References

SHOWING 1-10 OF 63 REFERENCES
Signal Multiplexing and Single-Neuron Computations in Lateral Intraparietal Area During Decision-Making
TLDR
Recording single neuron spiking activity in LIP during a well-studied moving-dot direction–discrimination task and manipulating whether a saccade target was present in the RF during decision-making shows that cells multiplex decision signals with decision-irrelevant visual signals.
Neural Activity in Macaque Parietal Cortex Reflects Temporal Integration of Visual Motion Signals during Perceptual Decision Making
TLDR
Results demonstrate that LIP is involved in neural time integration underlying the accumulation of evidence in this task, and suggest that decision-related LIP responses, as well as behavioral choices and reaction times, can be explained by near-perfect time integration that stops when a criterion amount of evidence has been accumulated.
Neural Correlates of Prior Expectations of Motion in the Lateral Intraparietal and Middle Temporal Areas
TLDR
The results suggest that information about an immediately upcoming stimulus does not scale the sensory response, but rather changes the amount of evidence that must be accumulated to reach a decision in areas that are involved in planning action.
Dissociated functional significance of decision-related activity in the primate dorsal stream
During decision making, neurons in multiple brain regions exhibit responses that are correlated with decisions. However, it remains uncertain whether or not various forms of decision-related activity
Encoding and decoding in parietal cortex during sensorimotor decision-making
TLDR
This work examined the neural code in LIP at the level of individual spike trains using a statistical approach based on generalized linear models and derived an optimal decoder for heterogeneous, multiplexed LIP responses that could be implemented in biologically plausible circuits.
Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task
TLDR
A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception, suggesting that neurons in LIP integrate time-varying signals that originate in the extrastriate visual cortex.
Distinct Representations of a Perceptual Decision and the Associated Oculomotor Plan in the Monkey Lateral Intraparietal Area
TLDR
The results suggest that perceptual decision-making and action selection are different brain processes that only appear to be inseparable under particular behavioral contexts.
Representation of Accumulating Evidence for a Decision in Two Parietal Areas
TLDR
It is shown that reach-related neurons from the medial intraparietal area (MIP) exhibit a gradual modulation of their firing rates consistent with the representation of an evolving decision variable, for decisions communicated by a hand movement.
A selective impairment of motion perception following lesions of the middle temporal visual area (MT)
  • W. Newsome, EB Pare
  • Psychology, Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
TLDR
The results indicate that neural activity in MT contributes selectively to the perception of motion.
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