Functional dissection of a trigger enzyme: mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties.

@article{Gunka2010FunctionalDO,
  title={Functional dissection of a trigger enzyme: mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties.},
  author={Katrin Gunka and Joseph Alan Newman and Fabian M. Commichau and Christina Herzberg and Cleide V. Rodrigues and Lorraine Hewitt and Richard James Lewis and J{\"o}rg St{\"u}lke},
  journal={Journal of molecular biology},
  year={2010},
  volume={400 4},
  pages={
          815-27
        }
}
Any signal transduction requires communication between a sensory component and an effector. Some enzymes engage in signal perception and transduction, as well as in catalysis, and these proteins are known as "trigger" enzymes. In this report, we detail the trigger properties of RocG, the glutamate dehydrogenase of Bacillus subtilis. RocG not only deaminates the key metabolite glutamate to form alpha-ketoglutarate but also interacts directly with GltC, a LysR-type transcription factor that… CONTINUE READING
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