Functional dissection of a human Dr1-DRAP1 repressor complex.

  title={Functional dissection of a human Dr1-DRAP1 repressor complex.},
  author={Ken K-C Yeung and S Kim and Danny F Reinberg},
  journal={Molecular and cellular biology},
  volume={17 1},
The heterotetrameric Dr1-DRAP1 transcriptional repressor complex was functionally dissected. Dr1 was found to contain two domains required for repression of transcription. The tethering domain interacts with the TATA box binding protein and directs the repressor complex to the promoter. This tethering domain can be replaced by a domain conferring sequence-specific recognition to the repressor complex. In the absence of the tethering domain, Dr1 interacts with its corepressor DRAP1, but this… CONTINUE READING