Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.

@article{KunttasTatli2009FunctionalDO,
  title={Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.},
  author={Ezgi Kunttas-Tatli and Anasua Bose and Bhaskar Kahali and Clifton P. Bishop and Ashok P Bidwai},
  journal={Genesis},
  year={2009},
  volume={47 10},
  pages={
          647-58
        }
}
Repression by E(spl)M8 during inhibitory Notch (N) signaling (lateral inhibition) is regulated, in part, by protein kinase CK2, but the involvement of a phosphatase has been unclear. The studies we report here employ Tik, a unique dominant-negative (DN) mutation in the catalytic subunit of CK2, in a Gal4-UAS based assay for impaired lateral inhibition. Specifically, overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N… CONTINUE READING