Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process.

@article{Kammerer1986FunctionalDO,
  title={Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process.},
  author={William G Kammerer and U Deuschle and Reiner Gentz and Hermann Bujard},
  journal={The EMBO journal},
  year={1986},
  volume={5 11},
  pages={2995-3000}
}
After binding to a promoter Escherichia coli RNA polymerase is in contact with a region of about 70 bp. Around 20 bp of this sequence are transcribed. Information encoded within this transcribed region is involved in late steps of the functional program of a promoter. By changing such 'down-stream' sequences promoter strength in vivo can be varied more than 10-fold. By contrast, information for early steps of the promoter program such as recognition by the enzyme and formation of a stable… CONTINUE READING

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