Functional differentiation of a clone resembling embryonic cortical interneuron progenitors.

  title={Functional differentiation of a clone resembling embryonic cortical interneuron progenitors.},
  author={Hedong Li and Yu Ray Han and Caixia Bi and Jonathan L. Davila and Loyal A Goff and Kevin A. Thompson and Mavis R. Swerdel and Cynthia Camarillo and Christopher L. Ricupero and Ronald P. Hart and Mark R. Plummer and Martin Grumet},
  journal={Developmental neurobiology},
  volume={68 14},
We have generated clones (L2.3 and RG3.6) of neural progenitors with radial glial properties from rat E14.5 cortex that differentiate into astrocytes, neurons, and oligodendrocytes. Here, we describe a different clone (L2.2) that gives rise exclusively to neurons, but not to glia. Neuronal differentiation of L2.2 cells was inhibited by bone morphogenic protein 2 (BMP2) and enhanced by Sonic Hedgehog (SHH) similar to cortical interneuron progenitors. Compared with L2.3, differentiating L2.2… CONTINUE READING
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