Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model.

@article{Li2019FunctionalDB,
  title={Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model.},
  author={Jia-min Li and Ling-Yu Li and Yu-Xue Zhang and Zhe-Yue Jiang and Samwel Mchele Limbu and Fang Qiao and P. Passilly Degrace and Liqiao Chen and Mei‐Ling Zhang and Zhen‐Yu Du},
  journal={The British journal of nutrition},
  year={2019},
  volume={122 6},
  pages={
          625-638
        }
}
l-Carnitine is essential for mitochondrial β-oxidation and has been used as a lipid-lowering feed additive in humans and farmed animals. d-Carnitine is an optical isomer of l-carnitine and dl-carnitine has been widely used in animal feeds. However, the functional differences between l- and d-carnitine are difficult to study because of the endogenous l-carnitine background. In the present study, we developed a low-carnitine Nile tilapia model by treating fish with a carnitine synthesis inhibitor… 
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Methods Citations
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16 Citations

Effect of Adding L-carnitine to High-Fat/Low-Protein Diets of Common Carp (Cyprinus carpio) and the Mechanism of Regulation of Fat and Protein Metabolism

Adding L-carnitine to high-fat/low-protein diets can stimulate growth by enhancing lipolysis and protein synthesis in common carp by up-regulating the expression of cpt1 in the hepatopancreas and decreased theexpression of fasn and elovl6 to reduce the production and extension of lipids.

Dietary L-Carnitine Alleviates the Adverse Effects Caused by Reducing Protein and Increasing Fat Contents in Diet Juvenile Largemouth Bass (Micropterus salmoides)

Protein ingredients for formulation of fish feeds are expensive and have limited availability. Therefore, reducing dietary protein while increasing dietary fat content is a common practice in rearing…

Dietary l-carnitine regulates liver lipid metabolism via simultaneously activating fatty acid β-oxidation and suppressing endoplasmic reticulum stress in large yellow croaker fed with high-fat diets

This study provides the first evidence that dietary LC can improve lipid metabolism via simultaneously promoting FA β-oxidation capability and suppressing the ER stress pathway in fish.

L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli

This work provides a proof of concept for the de novo L-carnitine production in E. coli, which does not depend on petrochemical synthesis of achiral precursors, but makes use of renewable feedstocks instead.

Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update

Based on the “multiple hit” hypothesis, carnitine inhibits β-oxidation, improves mitochondrial dysfunction, and reduces insulin resistance to ameliorate NAFLD.

Effect of dietary methionine on growth performance, lipid metabolism and antioxidant capacity of large yellow croaker (Larimichthys crocea) fed with high lipid diets

Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase

These drugs stabilise the enzyme at pH and temperature without inhibiting the activity and acted synergistically with active-site directed pharmacological chaperones, enhancing by 4-fold the acid α-glucosidase activity in fibroblasts from three Pompe patients with added rhGAA.

Intestinal metabolomics of juvenile lenok (Brachymystax lenok) in response to heat stress

Changes in the metabolic profile within the intestine of lenok when challenged to acute and lethal heat stress (HS) are studied using no-target HPLC–MS/MS metabonomic analysis.

A machine-learning approach for predicting the effect of carnitine supplementation on body weight in patients with polycystic ovary syndrome

No significant relationship of dose-response was found in the dosage range of carnitine supplementation used in the present study, indicating the lower limit of carn itine supplementation dosage, 250 mg/day, could be used as a suitable dosage.

Peroxisome proliferator-activated receptor gamma is essential for stress adaptation by maintaining lipid homeostasis in female fish.

  • Xue WangQiang Ma Z. Du
  • Biology
    Biochimica et biophysica acta. Molecular and cell biology of lipids
  • 2022

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