Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model.

  title={Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model.},
  author={Jia-min Li and Ling-Yu Li and Yu-Xue Zhang and Zhe-Yue Jiang and Samwel Mchele Limbu and Fang Qiao and P. Passilly Degrace and Liqiao Chen and Mei‐Ling Zhang and Zhen‐Yu Du},
  journal={The British journal of nutrition},
  volume={122 6},
l-Carnitine is essential for mitochondrial β-oxidation and has been used as a lipid-lowering feed additive in humans and farmed animals. d-Carnitine is an optical isomer of l-carnitine and dl-carnitine has been widely used in animal feeds. However, the functional differences between l- and d-carnitine are difficult to study because of the endogenous l-carnitine background. In the present study, we developed a low-carnitine Nile tilapia model by treating fish with a carnitine synthesis inhibitor… 

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