Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR.

@article{Lawson2001FunctionalDB,
  title={Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR.},
  author={Thomas M Lawson and Stephen Man and Eddie C Y Wang and Sheila Williams and Nick Amos and Geraldine M.A. Gillespie and Paul A. H. Moss and Leszek K. Borysiewicz},
  journal={International immunology},
  year={2001},
  volume={13 11},
  pages={1383-90}
}
We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in all individuals. To determine whether the affinity of the expressed TCR for the HLA-A*0201/M1(58-66) complex could influence functional properties, M1(58-66)-specific clones… CONTINUE READING

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