Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme

@inproceedings{Goods2017FunctionalDB,
  title={Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme},
  author={Brittany A Goods and Amanda L. Hernandez and Daniel Elliot Lowther and Liliana E Lucca and Benjamin Andrew Lerner and Murat Gunel and Khadir Raddassi and Vlad Coric and David A. Hafler and J. Christopher Love},
  booktitle={PloS one},
  year={2017}
}
Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have been highly successful in the treatment of cancer. While PD-1 expression has been widely investigated, its role in CD4+ effector T cells in the setting of health and cancer remains unclear, particularly in the setting of glioblastoma multiforme (GBM), the most aggressive and common form of brain cancer. We examined the functional and molecular features of PD-1+CD4+CD25-CD127+Foxp3-effector cells in healthy… CONTINUE READING
Tweets
This paper has been referenced on Twitter 3 times. VIEW TWEETS