Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding.

@article{Gouardres2007FunctionalDB,
  title={Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding.},
  author={Christine Gouard{\`e}res and Honor{\'e} Mazarguil and Catherine Mollereau and Nicolas Chartrel and J{\'e}r{\^o}me Leprince and Hubert Vaudry and J-M. Zajac},
  journal={Neuropharmacology},
  year={2007},
  volume={52 2},
  pages={
          376-86
        }
}
By using an optimized [(35)S]GTPgammaS binding assay, the functional activities (potency and efficacy) of peptides belonging to three members of the RFamide family; Neuropeptide FF (NPFF), prolactin-releasing peptide (PrRP) and 26RFamide, were investigated on NPFF(1) and NPFF(2) receptors stably expressed in Chinese Hamster Ovary (CHO) cells. Despite their large differences in affinity and selectivity, all analogues tested behaved as agonists toward NPFF(1) and NPFF(2) receptors. High NaCl… CONTINUE READING

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