Functional differences among Xenopus nodal-related genes in left-right axis determination.

@article{Sampath1997FunctionalDA,
  title={Functional differences among Xenopus nodal-related genes in left-right axis determination.},
  author={Karuna Sampath and Abby M. S. Cheng and Andrew Frisch and Christopher V E Wright},
  journal={Development},
  year={1997},
  volume={124 17},
  pages={3293-302}
}
An association has been noted previously in chick, mouse and frog embryos between asymmetric nodal-related gene expression and embryonic situs, implying an evolutionarily conserved role in left-right specification. Of the four Xenopus nodal-related genes expressed during gastrulation, only Xnr-1 is re-expressed unilaterally in the left lateral plate mesoderm at neurula/tailbud stages. Here, we show that the asymmetric expression of Xnr-1 can be made bilaterally symmetric by right-sided… CONTINUE READING
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