Functional development of the dorsolateral prefrontal cortex: an analysis utlizing reversible cryogenic depression.

@article{Alexander1978FunctionalDO,
  title={Functional development of the dorsolateral prefrontal cortex: an analysis utlizing reversible cryogenic depression.},
  author={G. E. Alexander and Patricia S. Goldman},
  journal={Brain research},
  year={1978},
  volume={143 2},
  pages={233-49}
}
The dorsolateral prefrontal cortex of rhesus monkeys was functionally inactivated by local hypothermia as the monkeys performed spatial delayed-response and spatial delayed-alternation tasks at different stages of postnatal development. Cryogenic depression of prefrontal cortex at a temperature sufficient to induce 21--25% decrements in delayed-response performance in 34--36-month-old-monkeys, produced deficits of only 7--8% in 19--31-month-old and no detectable loss in younger monkeys, 9--16… CONTINUE READING
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