Functional deterioration of the liver by elevated inferior vena cava pressure: A proposed upper safety limit of pressure for maintaining liver viability in dogs

@article{Higashiyama1994FunctionalDO,
  title={Functional deterioration of the liver by elevated inferior vena cava pressure: A proposed upper safety limit of pressure for maintaining liver viability in dogs},
  author={Hiroshi Higashiyama and Masato Yamaguchi and Kaoru Kumada and Hideki Sasaki and Takahiro Yamaguchi and Kazue Ozawa},
  journal={Intensive Care Medicine},
  year={1994},
  volume={20},
  pages={124-129}
}
Abnormally elevated central venous pressure is considered to be an etiological factor in the onset of acute hepatic failure following modified Fontan operation. This paper hypothesises that an increase in inferior vena cava pressure (IVCP) after such an operation has adverse effects on hepatic energy status. Various degrees of venous hypertension were produced in 10 mongrel dogs by clamping the thoracic IVC with an active veno-venous shunt and varying its flow rate from 60–2.5 ml/min/kg… CONTINUE READING