Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells.

@article{Mahata2006FunctionalDO,
  title={Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells.},
  author={Bidesh Mahata and Saikat Mukherjee and Sumita Mishra and Arun Bandyopadhyay and Samit Adhya},
  journal={Science},
  year={2006},
  volume={314 5798},
  pages={471-4}
}
Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial (mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1-dependent pathway, where it induced import of endogenous cytosolic tRNAs, including tRNA(Lys), and restored mitochondrial function in a cybrid… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…