Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours.

@article{Kohler2008FunctionalDO,
  title={Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours.},
  author={Eva Maria Kohler and Adrian Derungs and Gabriele Daum and J{\"u}rgen Behrens and Jean Schneikert},
  journal={Human molecular genetics},
  year={2008},
  volume={17 13},
  pages={1978-87}
}
The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites. Each mutation in the MCR leads to the synthesis of a truncated APC product expressed in a colorectal tumour. The MCR extends from the 3' border of the first 20R coding region to approximately the middle of the third 20R coding region, reflecting both positive… CONTINUE READING

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WNT signaling in the normal intestine and colorectal cancer.

Frontiers in bioscience : a journal and virtual library • 2007

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