Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry

@article{Teicher2000FunctionalDI,
  title={Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry},
  author={Martin H. Teicher and Carl M. Anderson and Ann Polcari and Carol A. Glod and Luis C. Maas and Perry F. Renshaw},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={470-473}
}
Attention-deficit/hyperactivity disorder is a highly heritable and prevalent neuropsychiatric disorder estimated to affect 6% of school-age children. Its clinical hallmarks are inattention, hyperactivity and impulsivity, which often respond substantially to treatment with methylphenidate or dextroamphetamine. Etiological theories suggest a deficit in corticostriatal circuits, particularly those components modulated by dopamine. We developed a new functional magnetic resonance imaging procedure… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Striatal dysfunction in attention deficit and hyperkinetic disorder.
TLDR
Low striatal activity, partially reversible with methylphenidate, appears to be a cardinal feature in ADHD. Expand
Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study.
TLDR
The results suggest that ADHD is characterized by atypical frontal-striatal function and that methylphenidate affects striatal activation differently in ADHD than in healthy children. Expand
Objective measurement of hyperactivity and attentional problems in ADHD.
TLDR
The relative inability of boys with ADHD to sit still can be objectively verified, and "fidgeting" appears to consist of more frequent, larger amplitude, whole body movements. Expand
Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder.
TLDR
The location of hypoperfused structures in cognitive disorders of childhood is consistent with a role for an early hypoxic-ischemic event in their origin. Expand
DOPA Decarboxylase Activity in Attention Deficit Hyperactivity Disorder Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study
TLDR
It is hypothesized that the prefrontal dopaminergic abnormality in ADHD adults is secondary and results from an interaction of the primary subcortical dopamine deficit with processes of neural maturation and neural adaptation. Expand
The Role of Motor Excess and Instrumented Activity Measurement in Attention Deficit Hyperactivity Disorder
  • W. Tryon
  • Psychology, Medicine
  • Behavior modification
  • 1993
TLDR
Results of content-valid instrumented behavioral measurements show that ADHD children are pervasively hyperactive, consistent with recent research showing activity to be an important aspect of temperament and a well-documented factor of externalizing disorders of childhood. Expand
Reduced brain metabolism in hyperactive girls.
TLDR
The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD, and there were no statistically significant differences in global or regional CMRglu between ADHD and normal adolescents. Expand
Ontario Child Health Study: prevalence of attention deficit disorder with hyperactivity.
TLDR
There were no significant differences in the prevalence of ADDH by age or urban-rural status, but the disorder was significantly more common in boys than in girls. Expand
Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors.
TLDR
The significant association between metabolic changes in the frontal and temporal cortices and in the cerebellum and D2 receptor suggests that methylphenidate's metabolic effects in these brain regions are due in part to dopamine changes and that differences in D2 receptors may be one of the mechanisms accounting for the variability in response to methyl phenidate. Expand
A Critique of Current Diagnostic Criteria for Attention Deficit Hyperactivity Disorder: Clinical and Research Implications
  • R. Barkley
  • Psychology, Medicine
  • Journal of developmental and behavioral pediatrics : JDBP
  • 1990
TLDR
A number of suggestions for revision of these criteria are provided that can be incorporated into current clinical and research practices to improve the rigor and discriminative validity of the criteria for ADHD. Expand
...
1
2
3
...