Functional decline in patients with and without peripheral arterial disease: predictive value of annual changes in levels of C-reactive protein and D-dimer.

@article{McDermott2006FunctionalDI,
  title={Functional decline in patients with and without peripheral arterial disease: predictive value of annual changes in levels of C-reactive protein and D-dimer.},
  author={Mary M McDermott and Kwang-Hyeon Liu and Jack Guralnik and Luigi Ferrucci and David Vincent Green and Philip Greenland and Lu Tian and Michael H. Criqui and Carol Lo and Nehal El Rifai and Paul M. Ridker and Jane Zheng and William H. Pearce},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2006},
  volume={61 4},
  pages={
          374-9
        }
}
BACKGROUND Inflammation may be a potential mechanism of aging-related functional decline. We determined whether greater annual increases in levels of high sensitivity C-reactive protein (hsCRP) and D-dimer predicted greater decline in functioning among persons with and without lower extremity peripheral arterial disease (PAD). METHODS We prospectively studied 296 men and women with PAD and 191 without PAD. Objective measures of functioning, hsCRP, and D-dimer were obtained at baseline and… CONTINUE READING

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