Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology

  title={Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology},
  author={Petra Sabine Eisele and Christoph Handschin},
  journal={Seminars in Immunopathology},
Skeletal muscle is an organ involved in whole body movement and energy metabolism with the ability to dynamically adapt to different states of (dis-)use. At a molecular level, the peroxisome proliferator-activated receptor γ coactivators 1 (PGC-1s) are important mediators of oxidative metabolism in skeletal muscle and in other organs. Musculoskeletal disorders as well as obesity and its sequelae are associated with PGC-1 dysregulation in muscle with a concomitant local or systemic inflammatory… CONTINUE READING
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