Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine

@inproceedings{Franceschini2012FunctionalCI,
  title={Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine},
  author={Alessia Franceschini and A. Sukumaran Nair and Tanja Bele and Arn Mjm van den Maagdenberg and Andrea Nistri and E. Fabbretti},
  booktitle={BMC Neuroscience},
  year={2012}
}
BackgroundEnhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is difficult to study this process in vivo, we investigated functional crosstalk between macrophages and sensory neurons in primary cultures from trigeminal sensory ganglia of wild… CONTINUE READING
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