Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis

  title={Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis},
  author={Chunmei Wang and Antonio Cigliano and Salvatore Delogu and Julia Armbruster and Frank Dombrowski and Matthias Evert and Xin Jane Chen and Diego F Calvisi},
  booktitle={Cell cycle},
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, with limited treatment options. AKT/mTOR and Ras/MAPK pathways are frequently deregulated in human hepatocarcinogenesis. Recently, we generated an animal model characterized by the co-expression of activated forms of AKT and Ras in the mouse liver. We found that concomitant activation of AKT/mTOR and Ras/MAPK cascades leads to rapid liver tumor development in AKT/Ras mice, mainly through mTORC1… CONTINUE READING


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Increased lipogenesis , induced by AKTmTORC 1RPS 6 signaling , promotes development of human hepatocellular carcinoma

  • DF Calvisi, C Wang, C Ho, S Ladu, SA Lee, S Mattu
  • Gastroenterology
  • 2011

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