Functional coupling of nitric oxide synthase and soluble guanylyl cyclase in controlling catecholamine secretion from bovine chromaffin cells.

@article{Schwarz1998FunctionalCO,
  title={Functional coupling of nitric oxide synthase and soluble guanylyl cyclase in controlling catecholamine secretion from bovine chromaffin cells.},
  author={Petra M. Schwarz and Fernando Rodr{\'i}guez-Pascual and Doris Koesling and Manuel Torres and Ulrich Foerstermann},
  journal={Neuroscience},
  year={1998},
  volume={82 1},
  pages={255-65}
}
This study was designed to evaluate whether the enzymes of the nitric oxide/cyclic-GMP pathway, nitric oxide synthase and soluble guanylyl cyclase, are functionally coupled in controlling catecholamine secretion in primary cultures of bovine chromaffin cells. In immunocytochemical studies, 80-85% of the tyrosine hydroxylase-positive chromaffin cells also possessed phenylethanolamine-N-methyltransferase, f1p4cating their capability to synthesize epinephrine. Immunoreactivity for neuronal-type… CONTINUE READING

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