Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.

@article{Kathoefer2000FunctionalCO,
  title={Functional coupling of human beta 3-adrenoreceptors to the KvLQT1/MinK potassium channel.},
  author={Sven Kathoefer and Wei Zhang and Christoph Karle and Dierk Thomas and Wolfgang H. Sch{\"o}ls and Johann Kiehn},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 35},
  pages={26743-7}
}
The slow component of the delayed rectifier potassium current (IKs) plays an important role during repolarization in the human heart. Life-threatening arrhythmias can be triggered by sympathetic stimulation, presumably acting on IKs. The ion channel responsible for the IKs current is made of two proteins, the KvLQT1 protein and the MinK protein. In this study, we investigated the effects of adrenergic stimulation on the KvLQT1/MinK channel by coexpressing KvLQT1/MinK channels with the human… CONTINUE READING

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