Functional coupling of gamma-aminobutyric acid receptors to chloride channels in brain membranes.

@article{Harris1985FunctionalCO,
  title={Functional coupling of gamma-aminobutyric acid receptors to chloride channels in brain membranes.},
  author={R. Adron Harris and Andrea M. Allan},
  journal={Science},
  year={1985},
  volume={228 4703},
  pages={1108-10}
}
gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in mammalian brain, is believed to act by increasing membrane conductance of chloride ions. In this study it was found that GABA agonists increased the uptake of chloride-36 by cell-free membrane preparations from mouse brain. This influx was rapid (less than 5 seconds), and 13 micromolar… CONTINUE READING