Functional coupling of chloride–proton exchanger ClC-5 to gastric H+,K+-ATPase

@inproceedings{Takahashi2014FunctionalCO,
  title={Functional coupling of chloride–proton exchanger ClC-5 to gastric H+,K+-ATPase},
  author={Yuji Takahashi and Takuto Fujii and Kyosuke Fujita and Takahiro Shimizu and Taiga Higuchi and Yoshiaki Tabuchi and Hisato Sakamoto and Ichiro Naito and Koji Manabe and Shinichi Uchida and Sei Sasaki and Akira Ikari and Kazuhiro Tsukada and Hideki Sakai},
  booktitle={Biology open},
  year={2014}
}
It has been reported that chloride-proton exchanger ClC-5 and vacuolar-type H(+)-ATPase are essential for endosomal acidification in the renal proximal cells. Here, we found that ClC-5 is expressed in the gastric parietal cells which secrete actively hydrochloric acid at the luminal region of the gland, and that it is partially localized in the… CONTINUE READING