Functional coupling between metabotropic glutamate receptors and G proteins in rat brain membranes.


Functional activation of GTP-binding (G) proteins coupled with metabotropic glutamate receptors was evaluated in rat brain membranes. L-Glutamate stimulated the high-affinity GTPase activity in cerebral cortical, hippocampal, and striatal membranes with a mean concentration eliciting a half-maximal response (EC50) of 4.8, 1.6, and 4.9 microM, respectively… (More)