Functional coordination of microtubule-based and actin-based motility in melanophores

@article{Rodionov1998FunctionalCO,
  title={Functional coordination of microtubule-based and actin-based motility in melanophores},
  author={V. I. Rodionov and Andrew J Hope and Tatyana M Svitkina and Gary G. Borisy},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={165-169}
}
The fish melanophore has been considered the exemplar of microtubule-based organelle transport. In this system, a radial array of uniformly polarized microtubules [1] provides a framework on which dynein-related and kinesin-related motors drive pigment granules toward the minus or plus ends, respectively [2-4]. Stimulation of minus-end motors accounts satisfactorily for aggregation of granules at the cell center. Rapid dispersion is clearly microtubule-dependent; however, the uniform… CONTINUE READING
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