Functional coordination of alternative splicing in the mammalian central nervous system

@article{Fagnani2006FunctionalCO,
  title={Functional coordination of alternative splicing in the mammalian central nervous system},
  author={Matthew M Fagnani and Yoseph Barash and Joanna Y. Ip and Christine Misquitta and Qun Pan and Arneet L Saltzman and Ofer Shai and Leo J. Lee and Aviad Rozenhek and Naveed Mohammad and Sandrine Willaime-Morawek and Tomas Babak and Wen Ni Zhang and Timothy R. Hughes and Derek van der Kooy and Brendan J. Frey and Benjamin J. Blencowe},
  journal={Genome Biology},
  year={2006},
  volume={8},
  pages={R108 - R108}
}
BackgroundAlternative splicing (AS) functions to expand proteomic complexity and plays numerous important roles in gene regulation. However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood.ResultsUsing quantitative AS microarray profiling, we have identified a large number of widely expressed mouse genes that contain single or… CONTINUE READING

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