• Corpus ID: 19539317

Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton.

@article{Favier1996FunctionalCB,
  title={Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton.},
  author={By V. Favier and Filippo M. Rijli and Catherine Fromental-Ramain and Valérie Fraulob and Pierre Chambon and Pascal Doll{\'e}},
  journal={Development},
  year={1996},
  volume={122 2},
  pages={
          449-60
        }
}
The Abdominal B-related Hoxa-10 gene displays similar expression patterns in the differentiating forelimbs and hindlimbs of the mouse, with preferential expression around the humeral and femoral cartilages and more diffuse expression in distal regions. We found that a targeted disruption of Hoxa-10 has almost no effect in the forelimbs, while it affects the proximal hindlimb skeleton. The alterations were located along the dorsolateral side of the femur (labium laterale), with an enlargement… 

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