Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein

@article{Liu2004FunctionalCO,
  title={Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein},
  author={Han Liu and Bing Chen and Hui Xiong and Qiu-hua Huang and Qinghua Zhang and Zhugang Wang and Boliang Li and Zhu Chen and Sai-juan Chen},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3385-3394}
}
The EEN (extra eleven nineteen) gene was originally cloned from a case of acute myeloid leukemia M5 subtype with translocation t (11; 19)(q23; p13), in which EEN was fused with MLL. To explore the involvement of EEN in leukemogenesis caused by MLL-EEN, we studied the transformation potential of the MLL-EEN fusion protein. MLL-EEN had oncogenic features, while, as a control, MLLΔ, the truncated form of MLL lacking the EEN moiety, did not show any oncogenic potential. MLL-EEN exerted a dominant… CONTINUE READING
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