Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove

@article{MusierForsyth1992FunctionalCO,
  title={Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove},
  author={Karin Musier-Forsyth and Paul R. Schimmel},
  journal={Nature},
  year={1992},
  volume={357},
  pages={513-515}
}
THE functional analysis of determinants on RNA has been largely limited to molecules that contain naturally occurring ribonucleotides, so little is known about the role of 2′-hydroxyl groups in protein–RNA recognition. A single base pair (G3·U70) in the acceptor stem of tRNAAla is the principal element for specific recognition by Escherichia coli alanine… CONTINUE READING