Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin.

@article{Nielsen2006FunctionalCU,
  title={Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin.},
  author={Mark G. Nielsen and Justin M Caserta and Sarah J Kidd and Christopher M Phillips},
  journal={Evolution & development},
  year={2006},
  volume={8 1},
  pages={23-9}
}
How do proteins evolve while maintaining their function? Previous studies find a highly stringent structure/function relationship between the Drosophila melanogaster testis-specific tubulin beta2 and the spermtail axoneme, such that small changes in the beta2 protein render it unable to generate a motile axoneme. This raises the question, how does beta2 evolve while maintaining its function? To address this question we cloned full- and partial-length beta2 sequences from 17 species of… CONTINUE READING