Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution.

@article{Gailey2006FunctionalCO,
  title={Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution.},
  author={Donald A. Gailey and Jean-Christophe Billeter and Jim Liu and Frederick Bauzon and Jane B. Allendorfer and Stephen F Goodwin},
  journal={Molecular biology and evolution},
  year={2006},
  volume={23 3},
  pages={633-43}
}
Male sexual behavior in the fruit fly Drosophila melanogaster is regulated by fruitless (fru), a sex-determination gene specifying the synthesis of BTB-Zn finger proteins that likely function as male-specific transcriptional regulators. Expression of fru in the nervous system specifies male sexual behavior and the muscle of Lawrence (MOL), an abdominal muscle that develops in males but not in females. We have isolated the fru ortholog from the malaria mosquito Anopheles gambiae and show the… CONTINUE READING

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