Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.

@article{Miura2002FunctionalCF,
  title={Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.},
  author={Shinji Miura and J Gan and Joseph Brzostowski and Michael J Parisi and Charles J Schultz and Constantine Londos and Brian Oliver and Alan R. Kimmel},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 35},
  pages={32253-7}
}
Intracellular neutral lipid storage droplets are essential organelles of eukaryotic cells, yet little is known about the proteins at their surfaces or about the amino acid sequences that target proteins to these storage droplets. The mammalian proteins Perilipin, ADRP, and TIP47 share extensive amino acid sequence similarity, suggesting a common function. However, while Perilipin and ADRP localize exclusively to neutral lipid storage droplets, an association of TIP47 with intracellular lipid… CONTINUE READING
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