Functional conservation and innovation of amphioxus RIP1-mediated signaling in cell fate determination.

@article{Li2011FunctionalCA,
  title={Functional conservation and innovation of amphioxus RIP1-mediated signaling in cell fate determination.},
  author={Jun Li and Shaochun Yuan and Lin Qi and Shengfeng Huang and Guangrui Huang and Manyi Yang and Liqun Xu and Yuxin Li and Renwei Zhang and Yingcai Yu and Shangwu Chen and Anlong Xu},
  journal={Journal of immunology},
  year={2011},
  volume={187 8},
  pages={3962-71}
}
Recently, receptor interacting protein (RIP)-1 has been recognized as an intracellular sensor at the crossroads of apoptosis, necroptosis, and cell survival. To reveal when this crucial molecule originated and how its function in integrating stress signals evolved, in this study we report on two RIP1 homologs in Chinese amphioxus (Branchiostoma belcheri tsingtauense), designated B. belcheri tsingtauense RIP1a and B. belcheri tsingtauense RIP1b. Phylogenetic analysis indicates that they are… CONTINUE READING