Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes.

Abstract

The origin of new exons is an important mechanism for proteome diversity. Here, we report the recurrent origination of new exons in mammalian chromodomain Y-like (CDYL) genes and the functional consequences associated with the acquisition of the new exons. Driven by positive selection, the newly evolved longer peptide exhibits weaker transcription repression activity and attenuates the repression activity of the old form, suggesting that the acquisition of the new exons is functionally significant.

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@article{Li2007FunctionalCO, title={Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes.}, author={Xin Li and Jing Liang and Haijing Yu and Bing Su and Chunjie Xiao and Yongfeng Shang and Ruiping Wang}, journal={Trends in genetics : TIG}, year={2007}, volume={23 9}, pages={427-31} }